I understand it’s being misused by people who don’t need it, particularly in the entertainment industry. But I’m almost 400 lbs and my eating is worse than it’s ever been and I’m just in desperate need to rid myself of this obsession with always eating more no matter what. Does anyone here have any experience with it? I’ve heard it just works by making you nauseous but I’ve read elsewhere that that’s just a common side effect. At this point I’m nauseous most of the time anyway.
I had a colleague tell me that GLP-1s inhibit individual fat cell (adipocyte) growth, but can ultimately lead to adipocyte proliferation, especially if lifestyle modifications aren’t made, and that this is a major factor in rebound weight gain. Can’t speak to the veracity myself and am having trouble interpreting the literature off-hand.
This sort of detail is well beyond my level of expertise. All I know is that at this point they appear to work about as well as anything else and be a lot more comfortable that hardcore calorie counting and denial for a lot of people, with usually tolerable side effects. Some evidence suggests long term success and some suggests that they’re just like everything else. As far as I know there is no data yet on whether it is safe to spend a lifetime going on and off them as one would expect to end up doing with any diet regime; which would be relevant if they have about average long term results.
Below Lydmila linked a combo therapy which seems to have interesting results, so that’s exciting.